Molecular Formula | C8H11ClN2 |
Molar Mass | 170.64 |
Density | 1.117 |
Boling Point | 254℃ |
Flash Point | 108℃ |
Storage Condition | under inert gas (nitrogen or Argon) at 2–8 °C |
Physical and Chemical Properties | This product is liquid, insoluble in water, soluble in toluene. |
Use | 2-chloro-5-ethylaminomethylpyridine is an intermediate of the insecticide nenpyridine. |
production method | the preparation method is as follows. Using 2-chloro-5-chloromethylpyridine as raw material, it reacts with ethylamine in a solvent to produce a product. Using 3-cyano-6-chloropyridine and ethylamine aqueous solution in an ethanol suspension with Rh/Al as the catalyst, hydrogen is passed at normal pressure. After the reaction, the catalyst is filtered to remove the catalyst, and the product is obtained by post-treatment. The toluene solution of acetaldehyde is added to the toluene solution of 5-chloromethyl-2-aminopyridine, the reaction temperature is 21~22 ℃, the reaction is stirred for 2h, then sodium borohydride is added in batches in the solution, the reaction is 3h, hydrochloric acid is added to adjust the pH = 7, the solvent is evaporated, the residue is added to alkali solution to adjust the pH = 11.5, and the product is extracted and concentrated with toluene. |